genotoxic effects of 2-methoxy and 2-methyl benzofuran phenylmethyl imidazole on mcf-7 cell line
Authors
abstract
similar resources
genotoxic effects of some l-[(benzofuran-2-yl)-phenylmethyl]-imidazoles on mcf-7 cell line
increased exposure to estrogen has been associated with the risk of breast cancer. substituted benzofuran derivatives with inhibitory effects on estrogen synthesis could be considered as a potential approach to reduce the risk of breast cancer. the study of cytotoxic effects of these compounds has suggested involvement of other mechanisms such as dna damage. in the current study we have investi...
full textcytotoxic effects of some 1-[(benzofuran-2-yl)-phenylmethyl]-imidazoles on mcf-7 and hela cell lines
aromatase inhibitors have been used as a second line therapy after tamoxifen, in estrogen-receptor positive (er+) women to reduce estrogen concentration in plasma and breast tumors. it has been shown that benzofuran(phenylmethyl)imidazoles are potent aromatase inhibitors at nano-molar concentrations, about 1000 times more potent than aminoglutetimide. in this study, cytotoxic activity of some o...
full textThe Genotoxic and Cytotoxic Effects of Bisphenol-A (BPA) in MCF-7 Cell Line and Amniocytes
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification...
full textDesign and Synthesis of 2-Methyl and 2-Methyl-4-Nitro Imidazole Derivatives as Antifungal Agents
Two series (a and b) of N- substituted heteroaromatic compounds related to clotrimazole were synthesized. Imidazole ring of the clotrimazole was replaced by 2-methylimidazole in series a, and by 2-methyl-4-nitroimidazole in series b. O-cholortrityl moiety of clotrimazole was also replaced by trityl, mono or dimethoxy trityl. Chemical structures...
full textthe genotoxic and cytotoxic effects of bisphenol-a (bpa) in mcf-7 cell line and amniocytes
bisphenol-a (bpa) is an industrial xenoestrogen used widely in our living environment. recently, several studies suggested that bpa has destructive effects on dna and chromosomes in normal body cells via estrogen receptors (er). therefore, bpa could be considered as an important mediator in many diseases such as cancer. however, there are still many controversial issues which need clarification...
full textThe Genotoxic and Cytotoxic Effects of Bisphenol-A (BPA) in MCF-7 Cell Line and Amniocytes
Bisphenol-A (BPA) is an industrial xenoestrogen used widely in our living environment. Recently, several studies suggested that BPA has destructive effects on DNA and chromosomes in normal body cells via estrogen receptors (ER). Therefore, BPA could be considered as an important mediator in many diseases such as cancer. However, there are still many controversial issues which need clarification...
full textMy Resources
Save resource for easier access later
Journal title:
research in pharmaceutical sciencesجلد ۷، شماره ۵، صفحات ۰-۰
Hosted on Doprax cloud platform doprax.com
copyright © 2015-2023